Vol 1, No 2 (2017)

Review Article

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    Background and Objectives: The most common type of hair loss is androgenetic alopecia. Mesotherapy is considered a controversial treatment for this condition. The aim of this study was to examine the safety and efficacy of mesotherapy in the treatment of androgenetic alopecia.
    Methods: A systematic review was conducted to identify and evaluate relevant studies on mesotherapy for the treatment of androgenetic alopecia. The Cochrane Library, PubMed, Embase, Scopus, and Web of Science were searched until November 2017. The grey literature and references of key studies were also scanned for additional citations. In addition, quality assessment of studies was conducted using the Jadad scale.
    Results: Five studies including 344 patients were considered eligible for the review. Of five studies included in this review, three were randomized controlled trials (RCTs) and two were non-RCTs. In previous studies, mesotherapy was performed using dutasteride, minoxidil, and finasteride. As the analysis revealed, quality of retrieved studies was poor. The results showed that mesotherapy leads to the improvement of efficacy outcomes. However, in one study, mesotherapy was not shown to be effective regarding some outcomes. No significant adverse effects were reported for mesotherapy.
    Conclusions: Although the findings of previous studies suggest that mesotherapy is a safe and effective treatment for androgenetic alopecia, further research is needed to confirm this finding.

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    Background: This study aims to investigate the effectiveness of mechanical thrombectomy compared with thrombolytic therapy in patients with acute stroke.
    Methods: This study is a systematic review on clinical studies, as the Cochrane library, PubMed, Google Scholar, Web of Science, and Embase databases were searched. The time span selected to retrieve articles is 1990 to 2017. The quality of the articles found was evaluated by the CONSORT checklist. Fixed effects and random effects models were employed for meta-analysis. Results were subject to sensitivity analysis in specified curtained interval, CMA (Comprehensive Meta-Analysis software): 2 software was used to carry out the meta-analysis task, and alpha was set to 5%.
    Results: The eight papers found met the inclusion criteria. Patients in mechanical thrombectomy group had a significantly higher improvement rate compared to the thrombolytic therapy group [OR 1.71 (1.182.48), P = 0.005]. There were no significant differences between mechanical thrombectomy and thrombolytic therapy groups regarding intracerebral hemorrhage ([OR 1.03 (0.71 - 1.49), P = 0.88]). Mechanical thrombectomy was more effective in reducing mortality rate of patients, however, this difference was not significant ([OR 0.84 (0.67 - 1.05), P = 0.12]). The effectiveness of mechanical thrombectomy is superior to thrombolytic therapy based on the improvement rate, 90-day mortality and symptoms of intracerebral hemorrhage OR: 2.23 (1.77 - 2.81), P < 0.00001; OR 0.79 (0.60 - 1.05), P = 0.10, and OR 1.02 (0.61 - 1.70), P = 0.95, respectively.
    Conclusions: Through some good criteria for selecting appropriate patients, mechanical thrombectomy can be superior to thrombolytic therapy in patients with acute stroke.