A Safety and Efficacy of Stem Cell Therapeutics in Wound Healing: A Rapid Review of Available Evidence
Safety and Efficacy of stem cell
Context: skin and wound health a serious public health problem with high morbidity and mortality rates worldwide. Although there are different treatment options presented, there is no agreement on the best treatment for severe burns and wound problems as of yet. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. The rapid review was performed to assess the efficacy and possible mechanisms of stem cells in wound healing.
Methods: This is a rapid review of the evidence for the potential effects of stem cell on wound healing, which intended to create a policy guide. To do so, health technology assessment studies indexed in PubMed, Scopus and Scholar on March 13, 2021 were searched using the keywords, including stem cell effects and wound healing. In addition, references of recovered studies were checked to ensure through the capture of the literature. Studies on the safety and efficacy of stem cell on wound healing, both in Persian or English, were included.
Results: In total 92 titles were identified, which after eliminating duplicates and applying inclusion criteria, 22 were included. The overall review showed that stem cell therapy improved wound but more study is needed though it is promising. Also, studies showed using stem cell technology as a non-invasive way can be a good alternative to older treatments. Finally, Restrictions of this technology may include the need to improve cell delivery methods, cell viability, heterogeneity in the preparation of mesenchymal stem cells, and wound substrate. Further studies may be needed to determine its safety and efficiency.
Conclusions: Evidence on the safety and efficacy of stem cell on wound were very limited to make a decision but Studies showed that stem cell technology is a good alternative to traditional therapies. These findings also demonstrate the need for considering variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness.
2- B. S. Atiyeh, J. Ioannovich, C. A. Al-Amm, and K. A. El-Musa, “Management of acute and chronic open wounds: the importance of moist environment in optimal wound healing,” Current Pharmaceutical Biotechnology, vol. 3, no. 3, pp. 179–195, 2002
3- H. Nakagawa, S. Akita, M. Fukui, T. Fujii, and K. Akino, “Human mesenchymal stem cells successfully improve skin-substitute wound healing,” The British Journal of Dermatology, vol. 153, no. 1, pp. 29–36, 2005.
4- O. K. Lee, T. K. Kuo, W. M. Chen, K. D. Lee, S. L. Hsieh, and T. H. Chen, “Isolation of multipotent mesenchymal stem cells from umbilical cord blood,” Blood, vol. 103, no. 5, pp. 1669–1675, 2004.
5- P. A. Zuk, M. Zhu, P. Ashjian et al., “Human adipose tissue is a source of multipotent stem cells,” Molecular Biology of the Cell, vol. 13, no. 12, pp. 4279–4295, 2002.
6- Cherubino M, Rubin JP, Miljkovic N, Kelmendi-Doko A, Marra KG. Adipose-derived stem cells for wound healing applications. Annals of plastic surgery. 2011;66(2):210-5
7- Kanji S, Das H. Advances of stem cell therapeutics in cutaneous wound healing and regeneration. Mediators of inflammation. 2017;2017
8- Adipose-derived stem cells: effectiveness and advances in delivery in diabetic wound healing. Biomedicine & Pharmacotherapy. 2018;107:625-33
9- Hassan WU, Greiser U, Wang W. Role of adipose‐derived stem cells in wound healing. Wound repair and regeneration. 2014;2
10- You H-J, Han S-K. Cell therapy for wound healing. Journal of Korean medical science. 2014; 29(3):311.
11- Kosaric N, Kiwanuka H, Gurtner GC. Stem cell therapies for wound healing. Expert opinion on biological therapy. 2019;19(6):575-85
12- Lopes L, Setia O, Aurshina A, Liu S, Hu H, Isaji T, et al. Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research. Stem cell research & therapy. 2018; 9(1):1-16.
13- Otero-Vinas M, Falanga V. Mesenchymal stem cells in chronic wounds: the spectrum from basic to advanced therapy. Advances in Wound Care. 2016;5(4):149-63.
14- Gentile P, Garcovich S. Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects. International Journal of Molecular Sciences. 2021;22(4):1538.
15- Nita M, Pliszczyński J, Kowalewski C, Woźniak K, Eljaszewicz A, Moniuszko M, et al., editors. New Treatment of Wound Healing With Allogenic Acellular Human Skin Graft: Preclinical Assessment and In Vitro Study. Transplantation proceedings; 2020: Elsevier
16- Kim K, Blasco‐Morente G, Cuende N, Arias‐Santiago S. Mesenchymal stromal cells: properties and role in management of cutaneous diseases. Journal of the European Academy of Dermatology and Venereology. 2017;31(3):414-23.
17- Jayaraman P, Nathan P, Vasanthan P, Musa S, Govindasamy V. Stem cells conditioned medium: a new approach to skin wound healing management. Cell biology international. 2013;37(10):1122-8.
18- Portas M, Mansilla E, Drago H, Dubner D, Radl A, Coppola A, et al. Use of human cadaveric mesenchymal stem cells for cell therapy of a chronic radiation-induced skin lesion: A case report.
19- Domaszewska-Szostek A, Krzyzanowska M, Siemionow M. Cell-based therapies for chronic wounds tested in clinical studies. Annals of plastic surgery. 2019;83(6):e96-e109
20- Holm JS, Toyserkani NM, Sorensen JA. Adipose-derived stem cells for treatment of chronic ulcers: current status. Stem cell research & therapy. 2018;9(1):1-11
21- Zeng X, Tang Y, Hu K, Jiao W, Ying L, Zhu L, et al. Three-week topical treatment with placenta-derived mesenchymal stem cells hydrogel in a patient with diabetic foot ulcer: a case report. Medicine. 2017;96(51
22- Gang X, Sun C, Wang G. Mesenchymal stem cells improve healing of diabetic foot ulcer. Journal of diabetes research. 2017;2017
23- Masłowski L, Paprocka M, Czyżewska-Buczyńska A, Bielawska-Pohl A, Duś D, Grendziak R, et al. Autotransplantation of the adipose tissue-derived mesenchymal stromal cells in therapy of venous stasis ulcers. Archivum immunologiae et therapiae experimentalis. 2020;68(1):1-9.
24- Kirana S, Stratmann B, Prante C, Prohaska W, Koerperich H, Lammers D, et al. Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients. International journal of clinical practice. 2012;66(4):384-93
25- Luck J, Smith OJ, Malik D, Mosahebi A. Protocol for a systematic review of autologous fat grafting for wound healing. Systematic reviews. 2018;7(1):1-5
26- Malik D, Luck J, Smith OJ, Mosahebi A. A systematic review of autologous fat grafting in the treatment of acute and chronic cutaneous wounds. Plastic and Reconstructive Surgery Global Open
27- Eamon Francis, Laura Kearney, James Clover
Int J Burns Trauma. 2019; 9(1): 1–12. Published online 2019 Feb 15
|Issue||Vol 5, No 2 (2021)|
|Stem cell wound healing Safety Efficiency|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|