Tehran University of Medical Sciences Health Technology Assessment in Action 2645-3835 10 2 2026 07 22 405 405 EN Fakhraddin Daastari Department of Health Management, Policy, and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Abdoreza Mousavi Department of Health Management, Policy, and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Ali Akbari Sari Department of Health Management, Policy, and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Hedieh Sadat Zekri Department of Health Management, Policy, and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Alireza Darrudi Department of Health Economics and Management, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran Rajabali Daroudi Department of Health Management, Policy, and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2025 02 04 2025 06 29 Introduction: This study aimed to evaluate the HRQoL of the general Iranian population across all provinces using the European QoL 5-Dimension (EQ-5D) questionnaire. Methods: Data were collected from a nationwide survey conducted in 2021 across all 31 provinces of Iran, involving 27,704 adults. The intended data included responses to EQ-5D-3L health states, EuroQol Visual Analogue Scale scores, and participants’ socioeconomic characteristics. Finally, descriptive analyses were conducted using Stata 14 and Microsoft Excel 2019. Results: Pain/discomfort and anxiety/depression were the most prevalent problems across all provinces. In addition, the mean EQ-5D utility score was 0.87 (±0.15), ranging from 0.80 in North Khorasan to 0.91 in Alborz, Kermanshah, and Zanjan. For women, the mean score was 0.84 (±0.20), with a range of 0.77–0.90, indicating notable variation. In contrast, men demonstrated a higher mean score with less variation, at 0.90 (±0.14), ranging from 0.84 to 0.93. Conclusion: This study provided HRQoL scores for the general population across the provinces of Iran, revealing significant variations. These values can inform healthcare research and policymaking by identifying disparities in health status across regions. Given the relatively low HRQoL scores observed in certain provinces, it is imperative to plan and implement strategies to enhance health outcomes, particularly in vulnerable groups within those regions. https://htainaction.tums.ac.ir/index.php/hta/article/view/405 https://htainaction.tums.ac.ir/index.php/hta/article/download/405/231 https://htainaction.tums.ac.ir/index.php/hta/article/download/405/232