Tehran University of Medical Sciences Health Technology Assessment in Action 2645-3835 9 3 2025 08 18 371 371 Sayan Pratihar SRM College of Physiotherapy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Chennai, India Karthiga Rajasekaran SRM College of Physiotherapy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Chennai, India Shanmuga Priya Parasuraman SRM College of Physiotherapy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Chennai, India 2024 12 08 2025 02 16 BACKGROUND: Conventional rehabilitation methods have shown limited and transient improvements, necessitating personalized approaches in the diverse population of Cerebellar Ataxia. Wii Balance Board exergame training, integrating physical exercise with interactive video games, presents a novel and engaging neuro-rehabilitation strategy. OBJECTIVES: The primary objective of this study was to assess the clinical feasibility of implementation of Wii Balance Board-based exergame training among individuals with various forms of Cerebellar Ataxia. The secondary objective was to investigate the preliminary efficacy, and assess the enjoyment of the intervention. METHODS: The study incorporates a pilot randomized control trial and feasibility study design. We recruited 10 patients using a block randomization method. The Wii Balance Board training was administered for 18 sessions, 3 sessions per week, till 6 weeks. The primary outcomes of feasibility testing were evaluated through clinical research log documentation, while secondary outcomes of balance, ataxia severity rate, functional independence and enjoyment were assessed with mini-BESTest, SARA, FIMs and EEQ. Data were analyzed using descriptive statistics and non-parametric tests to evaluate changes in outcomes. RESULTS: The study enrollment rate was 77% (n=10). The Wii intervention group showed a 100% (n=5) retention rate compared to 80% (n=4) in the control group. The Wii intervention group demonstrated a tendency towards better outcomes at follow-up in SARA (p=0.063, effect size/RM =0.84) and Mini-BESTest (p=0.071, effect size/RM =0.79) but not in the case of FIM (p=0.794, effect size/RM =0.14), along with reported a moderate level of enjoyment. CONCLUSION: Wii Balance Board based-exergame training is considered feasible for implementation in clinical settings among individuals with various forms of Cerebellar Ataxia, that suggesting the conduction of a larger definitive study to further explore the intervention efficacy. https://htainaction.tums.ac.ir/index.php/hta/article/view/371 https://htainaction.tums.ac.ir/index.php/hta/article/download/371/187