Tehran University of Medical Sciences Health Technology Assessment in Action 2645-3835 9 3 2025 08 18 337 337 Hakimeh Mostafavi Health Equity Research Center (HERC), Tehran University of Medical Sciences (TUMS), Tehran, Iran. Amirhossein Takian 1. Health Equity Research Center (HERC), Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran 2. Department of Health Management, Policy & Economics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran 3. Department of Global Health & Public Policy, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran Sahar Mostafavi Ahvaz Jundishapur University of medical sciences, Ahvaz, Islamic Republic of Iran Ahad Bakhtiari Health Equity Research Center (HERC), Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran Efat Mohamadi Health Equity Research Center (HERC), Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran Fateme Yaftian Health Equity Research Center (HERC), Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran Alireza Olyaeemanesh 1. Health Equity Research Center (HERC), Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran 2. Department of Health Management, Policy & Economics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran 3. National Institute for Health Research, Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran 2024 09 15 2024 12 22 Background: Electronic prescribing (E-prescribing) is a novel digital tool that can provide a complete patient profile and further helps to avoid prescription errors. In this study, we aimed to evaluate the present state of E-prescribing in Iran, identify its process, and diagnose its software flaws. Methods: Semi-structured interviews with several user groups, health system executives, and patients were conducted for this qualitative study (concluded in 2022) and MAXQDA 11 software was used for coding and data management. Results: According to our interviews, E-prescribing process’s challenges include: a lack of appropriate culture, support for service providers, and physician cooperation; poor management; frequent system interruptions; extra workload imposed on pharmacies; and a failure to adapt systems for underprivileged areas. Moreover, the software themselves have a number of flaws, notably, inconsistent and missing medical codes, their inability to keep up with an increase in the workload, difficulty in connecting some older systems with the latest ones, and a lack of user-friendly interface. Conclusion: Despite E-prescribing system’s continual improvements, its further effective implementation in our country requires an ongoing interaction with all manners of stakeholders, enlisting their opinions, and resolving its problems as quickly as feasible. https://htainaction.tums.ac.ir/index.php/hta/article/view/337 https://htainaction.tums.ac.ir/index.php/hta/article/download/337/206