Tehran University of Medical Sciences Health Technology Assessment in Action 2645-3835 9 3 2025 08 18 317 317 Abdullah I Aedh Associate professor of internal medicine- Najran University- KSA Medicine and critical care consultant- Najran University Hospital 2024 06 21 2024 11 12 Background:Anti-hypertensive drugs are a crucial component of managing hypertension, and significant cause of morbidity and death globally. However, adherence to anti-hypertensive medications is often suboptimal, leading to poor blood pressure control and increased risk of cardiovascular events. Aim: To determine the elements affecting the Najran population's adherence to anti-hypertensive medication. Methods: An 18-year-old or older population who had been diagnosed with hypertension and were now using anti-hypertensive drugs participated in this cross-sectional study. Participants were asked to fill out a self-administered data collecting form to provide socio - demographics and adherence-related data. Anti-hypertensive medication adherence was evaluated using the Morisky Medication Adherence Scale (MMAS-8). To find determinants of adherence to anti-hypertensive drugs, bivariate and multivariate analyses were performed. Results: Among 208 participants, (57.2%) were married, had a secondary education (34.6%), worked for the government (36.1%), and lived mostly in cities (95.2%). The average score on the MMAS-8 was 4.66 plus 2.53, which indicates a moderate level of non-adherence to anti-hypertensive treatment. There were significant associations between MMAS-8 scores and sex, marital status, educational level, employment status, residency, source of knowledge, and duration of anti-hypertensive medications. Conclusion: Several factors are associated with non-adherence to anti-hypertensive medications among the Najran population in Saudi Arabia. Female sex, single marital status, primary education, private sector employment, and rural residency were independent predictors of non-adherence. These findings suggest that interventions to improve adherence to anti-hypertensive medications should consider these factors and be tailored to the specific needs and challenges faced by individuals in studied subgroups. https://htainaction.tums.ac.ir/index.php/hta/article/view/317 https://htainaction.tums.ac.ir/index.php/hta/article/download/317/207