Tehran University of Medical Sciences Health Technology Assessment in Action 2645-3835 7 3 2023 11 01 161 161 Ravindra Kalode MBBS, M. D. (Radio Diagnosis) from IGMC, Nagpur, Assistant Professor at Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, India Pranoti Kalode MBBS, DGO. from Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, Consultant at Kalode Hospital, Amravati, India 2023 02 18 2023 06 14 Context: The placenta performs a crucial function in nutrient exchange, but studying this tissue poses a number of challenges. Utilizing microfluidic and microfabrication technologies, a 3D placenta-on-a-chip model provides a biomimetic alternative for studying placental diseases and treatments. Objectives: Aim: To review and analyze the currently available placenta-on-chip data to study placental pathologies in patients. Methods: By systematically searching the PubMed, Scopus, and Science Direct databases, research papers that employed 3D printing techniques for the development of organoids and Organ-on-Chip (OoC) systems for in vitro experiments were gathered and scrutinized. Results: When exposed to glucose transfer, placenta-on-a-chip mimics the features of an in vivo human placenta. Microchips have the potential to become a platform for diagnostic purposes for placental diseases and a model for duplicating the important features of these diseases. Conclusions: The microfluidic placenta-on-a-chip platform holds promise as an affordable solution with versatile applications. However, research is essential to develop a comprehensive in vitro pregnancy model in the future to expand our understanding of feto-maternal communication. https://htainaction.tums.ac.ir/index.php/hta/article/view/161 https://htainaction.tums.ac.ir/index.php/hta/article/download/161/129